Clin Colorectal Cancer. While incidence and mortality have declined, it remains the leading cause of cancer death in the United States. They concluded that there was no difference in survival benefit between the two regimens but that FOLFOX was more commonly used, possibly due to fewer side effects, lower cost, and its effectiveness in treating stage 3 cancer. We went to the oncologist yesterday and he just said keep taking the pills for 2 more months and will have a CT scan in Jan to see if they have done any good. Oral chemotherapy in the form of pills, liquids, or tablets is a treatment option for some types and stages of cancer. The trial, which at one time had six different arms, underwent several modifications: In March 1999 to include oxaliplatin; in March 2000, when IFL became the standard of care; and in April 2001 to address IFL toxicity, which led to a dose reduction in the IFL arm. Neutropenia was more common with FOLFOX and dehydration with IFL, but these differences were not statistically significant. My husband says he doesn't want to know any more Well, I guess we have to hey Hi, so sorry to hear this has happened. Preference cookies enable a website to remember information that changes the way the website behaves or looks, like your preferred language or the region that you are in. We just seem to be in limbo don't we. For example, if the 5-year relative survival rate for a specific stage of esophageal cancer is 60%, it means that people who have that cancer are, on average, about 60% as likely as people who don't have that cancer to live . A Japanese multicenter phase II study of adjuvant chemotherapy with mFOLFOX6/CAPOX for stage III colon cancer treatment after D2/D3 lymphadenectomy. Each cycle of FOLFOX is 2 weeks long, and an individual may receive up to 12 cycles. This study investigated the change in outcomes over 10-years in patients with stage 3 colon cancer who received FOLFOX chemotherapy. FOLFOX is delivered in 2-week cycles. Marketing cookies are used to track visitors across websites. This came as a great shock as completely unexpected. So we went for his CT scan quite confident last week and then to see the oncologist yesterday hoping he'd get the all clear. Like you we were relatively shocked and speechless. Cancer Update 2023 - My complete colorectal cancer (colon cancer) journey, from diagnosis to Folfox Chemotheropy.Chapters:00:00 - Intro02:07 - Poop (yep, I s. . Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Adenocarcinoma of the lung usually evolves from the mucosal glands and . We are still awaiting the PET scan to find out the full picture and then we'll have to see what's next but basically he told us that as chemo had no effect the first time, there are chances it won't work in the future either, even if they change the drug Radio therapy is not possible due to the large area involved, and an operation is no good either, for the same reasons. Dr. Wright has served as a consultant for Tesaro and Clovis Oncology. gastrointestinal issues, such as diarrhea, nausea, and vomiting, neurological issues, such as headaches, loss of sensation, numbness, and tingling, skin problems, such as itchiness and rashes, oxaliplatin through an IV drip over 2 hours, a fluorouracil injection and infusion over 22 hours, a folinic acid injection or infusion over 2 hours, A 2016 study looked at FOLFOX as an adjuvant treatment. But we are only too aware that this may not last. See this image and copyright information in PMC. In this article, we break down everything you need to know about FOLFOX chemotherapy, including when its typically used, what it usually involves, and the most common side effects. You're browsing our sample library. We used All Clear insurance you could try them. 2022 Oct 30;8(11):e11305. Read More, In case of sale of your personal information, you may opt out by using the link Do Not Sell My Personal Information. Researchers suggested that this treatmentimproved the outcomes of these patients. 2012;17(12):1486-95. doi: 10.1634/theoncologist.2012-0190. They said they removed the tumour ok and that he would have to go through 12 cycles of Folfox chemo because of the 3 lymph nodes but that it was all very positive. Stage 4 colon cancer is late-stage cancer. "One year after they had been enrolled on the study, 58%, 71%, and 65% of patients were alive, respectively." Hong YS, Nam BH, Kim KP, Kim JE, Park SJ, Park YS, Park JO, Kim SY, Kim TY, Kim JH, Ahn JB, Lim SB, Yu CS, Kim JC, Yun SH, Kim JH, Park JH, Park HC, Jung KH, Kim TW. No survival difference was detected for the 2 groups. We then had to wait weeks for next treatment to start, which is a different chemo and also, like you, feel that we have wasted months letting the cancer spread when maybe an operation right at the start could have stopped it spreading. However, a 2017 study found survival rates for those with stage 4 colon cancer that metastasized to the liver and were candidates for removal of the liver metastases at the same time as colon surgery improved to up to 70% . Even though the prognosis of stage 3 colon cancer is encouraging, with a five-year relative survival rate of 72%, being diagnosed with it can be a lot to digest. Cure is not possible for most patients with metastatic colorectal cancer, although some patients who have limited involvement of distant organs (particularly restricted to the liver and/or lung) can be cured with surgery. Epub 2019 Apr 5. Bendell JC, Bekaii-Saab TS, Cohn AL, Hurwitz HI, Kozloff M, Tezcan H, Roach N, Mun Y, Fish S, Flick ED, Dalal D, Grothey A. Oncologist. The 10-year follow-up also confirmed the survival benefit given by oxaliplatin in stage 3 coloncancer. This website uses cookies to improve your experience. Another 2020 study compared the effectiveness of 3 months to 6 months of adjuvant chemotherapy using FOLFOX. This is referred to as metastatic (stage IV) colorectal cancer. The drugs used during FOLFOX and other types of chemotherapy can kill healthy cells in your body and lead to a variety of side effects. Analytics cookies help website owners to understand how visitors interact with websites by collecting and reporting information anonymously. What is the success rate of FOLFOX chemotherapy? This data came from 6 trials. He has coped well with all he has been through and I'm sure the chemo must have helped some. Also if you have the money, consider SIRT. After IROX, 45% of patients received 5-FU. These figures are estimates of how long people with a certain type of cancer and stage might live. Patients with Stage IIIC colon cancer have a 5-year survival rate of 28%. It is hard to come to terms with what they are telling you. I would dearly love to be a 2 in 4.2 million to one shot. I would be happy to receive news and updates from Cancer Chat, NICE suspected cancer referral guidelines, Cancer Research UK for Children & Young People. Researchers found that in the 213 participants with stage 3 colon cancer, the 5-year overall survival rate was. FOLFOX chemotherapy consists of leucovorin (folinic acid), 5-fluorouracil (Adrucil), . Tsuruta A, Yamashita K, Tanioka H, Tsuji A, Inukai M, Yamakawa T, Yamatsuji T, Yoshimitsu M, Toyota K, Yamano T, Nagasaka T, Okajima M. Drug Des Devel Ther. The findings show that panitumumab plus FOLFOX yields longer overall survival, . FOLFOX is usually used to treat colorectal cancer. The current 5-year survival rate for stage 4 colon cancer, according to the American Cancer Society, is 14%. All rights reserved. Saying that, I emailed the oncologist on Monday as by then we had a few days to take the news in, and I listed a lot of questions (like how was the cancer able to spread whilst my husband was on chemo and why wasn't it picked up on previous scans and/or the blood tests they do prior to each chemo session). I continued the treatment for 3 years 10 months and 2 weeks, 89 cycles. PMC Axitinib or bevacizumab plus FOLFIRI or modified FOLFOX-6 after failure of first-line therapy for metastatic colorectal cancer: a randomized phase II study. Read about the procedure, side effects, who is eligible, and more here. After 2 weeks , after the ct scan , they said the spot in the liver has increased to 11 mm and there is another tiny lesion so changed the whole treatment to folfox infusion with pump for 3 months and to see if the cancer will shrink and the liver surgeon can check if its operable . We'll assume you're ok with this, but you can opt-out if you wish. However, the duration of FOLFOX response is short and the researchers concluded that new treatments are urgently needed. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. At a median follow-up of 28 months, the median overall survival for patients treated with FOLFOX4 plus bevacizumab was 12.9 months vs 10.8 months for FOLFOX4 alone (P = .0018; hazard ratio [HR] for death, 0.76). What happens after 2 weeks of FOLFOX treatment for liver cancer? Stage IV colon cancer has a relative 5-year survival rate of about 14%. Read more to learn about the FOLFOX regimen, its side effects, success rates, and more. Make sure the insurance will cover you if you decide it is possible to go. He has also said that he had a meeting with the Liver team the previous day and that, according to them and from what they can see on the CT scan my husband did 2 weeks ago, the cancer may have also spread to the peritoneal cavity, making the cancer terminal. They found FOLFOX significantly increased the overall survival rate in patients who received at least eight cycles. Copyright 2019 Elsevier Inc. All rights reserved. This is just so hard to believe! This means that about 14% of people with stage IV colon cancer are likely to still be alive 5 years after they are diagnosed. Look it up. Hand-foot syndrome (palmar-plantar erythrodysesthesia) redness, pain or peeling of palms and soles. However, the findings reported at ASCO include results only from the 765 patients enrolled in the three final arms prior to lowering the IFL dose. I understand your situation completely. In contrast, after FOLFOX, 52% of patients were given irinotecan. The addition of cetuximab to FOLFIRI/FOLFOX also increased the overall response rate with the OR of 2.12 (P < 0.00001). According to the National Cancer Institute, FOLFOX is typically used as an adjuvant treatment (meaning in addition to the primary therapy) and for advanced cancers that have spread beyond your colon. Blood Cancer Awareness Month: 3 Stories of Strength from Survivors, What to Know About Fluorouracil (5FU) Chemotherapy. In honor of Blood Cancer Awareness Month, survivors share what they learned throughout their cancer journeys and advice for others with lymphoma. The researchers found that the 213 patients in the study had a 5-year overall survival rate of 77.9 percent. Dr. Goldberg noted that N9741 included a quality-of-life component that will be analyzed in the near future. He stressed that the availability of multiple effective agents offers the opportunity to customize treatment to individual patients, based on patient preferences regarding toxicity. Individuals typically receive FOLFOX through intravenous (IV) infusions at a chemotherapy clinic. 2022 Jan 6;29(1):209-220. doi: 10.3390/curroncol29010020. Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colon carcinoma: a 10-year experience of the Geisinger Medical Center. Ninety percent of . Bendell JC, Tournigand C, Swieboda-Sadlej A, Barone C, Wainberg ZA, Kim JG, Pericay C, Pastorelli D, Tarazi J, Rosbrook B, Bloom J, Ricart AD, Kim S, Sobrero AF. Our goal was to investigate the patterns and predictors of use for first-line FOLFOX and FOLFIRI. Paresthesias were significantly more common with FOLFOX. A subsequent post hoc analysis of survival 7 months later found an overall survival improvement in the FOLFOX arm (6.47 v 4.90 months; P = .04), although this unplanned look does not make this study positive. Although FOLFOX may improve the outlook of your cancer, it can also cause side effects. Next, researchers analyzed the overall and cancer-specific survival rates of these two groups. Adjuvant FOLFOX only reduces the risk of recurrence of colorectal cancer by 40%, so almost 50% of patients still die from the disease. A bittersweet moment. . For example, the primary treatment for colon cancer is often surgery. Unclassified cookies are cookies that we are in the process of classifying, together with the providers of individual cookies. The https:// ensures that you are connecting to the Last medically reviewed on March 29, 2022, People can take several steps to prepare for chemotherapy, including packing a bag for treatment and getting prescriptions in advance for drugs to. ROCHESTER, Minnesota-An interim analysis of the North American Intergroup Study N9741 suggests that oxaliplatin (Eloxatin, investigational in the United States) plus infusional fluorouracil (5-FU)/leucovorin (FOLFOX) may be the new standard of care for patients with metastatic colorectal cancer. Sorry to hear that so many of us are having the same issues Our oncologist was very nice and agreed to see us yesterday to go through our concerns as we weren't really happy to have to wait until after the PET and MRI scans for our next appointment on18th November and felt there were too many unanswered questions. I consent to the use of following cookies: Necessary cookies help make a website usable by enabling basic functions like page navigation and access to secure areas of the website. Chemosensitivity of various peritoneal cancer cell lines to HIPEC and PIPAC: comparison of an experimental duplex drug to standard drug regimens in vitro. I feel doctors don't seem too care any more praying is a waste of time just have hope left..he should have been seen September last year but they never sent for him now it's got worse by being left so long initially it's was stones he went in for and was in agony a whole year i really blame the hospital as last year he may have had a good chance and while getting stones out found the cancer earlier. Epub 2011 Dec 31. What Is Hodgkins Lymphoma (Hodgkins Disease)? This site uses different types of cookies. FOLFOX chemotherapy is widely used as an adjuvant treatment for advanced colon cancer. Differential Interactome Based Drug Repositioning Unraveled Abacavir, Exemestane, Nortriptyline Hydrochloride, and Tolcapone as Potential Therapeutics for Colorectal Cancers. Basically the doctor told us that we must consider quality of life too and as we had a holiday booked in December he said we should discuss in November whether it is possible to wait until January to start the treatment or whether it can't wait. The Dr said that my husband would have to have a pet scan and an MRI and that we'd see him again in 4 weeks' time for the next steps, where he'd tell us if the tumor is operable or not. (2019). While the role of chemotherapy is well established in NECs, data on NETs mostly derives from small studies, experts&rsquo . Each of the drugs in this combination is approved by the Food and Drug Administration (FDA) to treat cancer or conditions related to cancer. My comment to you is this, no matter what your going through, no matter how bad you feel, take it. Don't give up hope, there will be something out there for him. Patients were divided into three groups as FOLFOX-4, modified FOLFOX-6 (mFOLFOX-6), and mFOLFOX-4 for comparison of toxicity and disease-free survival (DFS) and overall survival (OS) times. 2019 Jun;37(3):415-423. doi: 10.1007/s10637-018-0641-6. We were then told that the tumours were static and that the scan now showed more secondaries in his lungs, one at the base of his spine and another suspect pelvic lymph node, also that there was now no chance of an operation to remove the bladder with the primary tumour. . Doctors commonly use it to treat colorectal cancer, particularly if it has spread beyond the colon. A four-drug chemotherapy regimen has produced the longest improvement in survival ever seen in a phase III clinical trial of patients with metastatic pancreatic cancer, one of the deadliest types of cancer.Patients who received the regimen, called FOLFIRINOX, lived approximately 4 months longer than patients treated with the current standard of care, gemcitabine (11.1 months compared with 6.8 . Metastatic colon cancer is when cancer spreads beyond the original site to other tissues and lymph nodes. They showed it as it was from the last scan. Ovarian stromal tumors: 70% . The bottom line. = Oxaliplatin. FOLFOX chemotherapy consists of leucovorin (folinic acid), 5-fluorouracil (Adrucil), and oxaliplatin (Eloxatin). Please enable it to take advantage of the complete set of features! What are the common side effects of FOLFOX chemotherapy? Can you integrate if function is not continuous? Clipboard, Search History, and several other advanced features are temporarily unavailable. Small Particle DEBIRI TACE as Salvage Therapy in Patients with Liver Dominant Colorectal Cancer Metastasis: Retrospective Analysis of Safety and Outcomes. Learn more. They may also use it to treat pancreatic cancer and some other cancers. and transmitted securely. Very much the same has happened with me too. The incidence of severe or potentially life threatening adverse events (grade 3/4) was comparable in both treatment arms. . FOLFOXIRI + Avastin has been estimated to double the 5-year overall survival rate when compared to FOLFIRI + Avastin. The safety of the cetuximab-FOLFIRI/FOLFOX treatment was evaluated. My skin is not what it was. FOLFOX uses the drugs folinic acid, fluorouracil, and oxaliplatin. FOLFOX is an abbreviation for a type of chemotherapy regimen typically used to treat colorectal cancer. 2. . Folinic acid, fluorouracil and oxaliplatin (FOLFOX). ps I did have RaaS wild type so I was allowed theOxaliplatin, you can only have this drug if you a RaaS wild type. No other authors have any conflicts of interest or disclosures. (DI) of each protocol, the Quality-Adjusted Survival, and the rate and type of second-line / third-line regimens chemotherapy. Xx. Chemotherapy is often used as adjuvant therapy after surgery to destroy remaining cancer cells. We have a similar situation, my husband was diagnosed with bladder cancer in June, with small suspect spot on his lung and inflammation in his pelvic lymph node. Is Stage 4 colon cancer usually terminal? We used logistic regression to assess demographic and clinical predictors for FOLFOX versus FOLFIRI. Each two-day FOLFOX treatment is repeated every 14 days. OX. I also believe my husband's case will have an initial review by the liver team today (prior to the scans) and so he may have a very early indication of what they want to do next when we see him tomorrow. l read your post with sadness and a large degree of understanding since l went through similar myself 7 years ago..Reading your post suggests that your son had bowel cancer,surgery to remove the tumour and follow up chemo,but this might not be the case,and was just on chemo which proved unable to have an impact. As for the holiday, well, I tried to call the travel insurance recommended by P&O and they quoted me 950 for 5 days!!! Raab GT, Lin A, Hillyer GC, Keller D, O'Neil DS, Accordino MK, Buono DL, Hur C, Kiran RP, Wright JD, Hershman DL, Neugut AI. Chemotherapy is often given as a combination of drugs, which usually works better than single drugs because different drugs kill cancer cells in different ways. F. = Fluorouracil. Cancer. We found that the majority of patients with stage IV colon cancer received FOLFOX (79.3%) first-line. What are the typical side effects of the Folfox regimen? Tables of possible side effects for commonly-used oncology regimens. Stage IV colon cancer has a relative 5-year survival rate of about 14%. "The stopping boundaries for the comparison of IFL and FOLFOX were crossed," Dr. Goldberg said. Overall survival was improved from 23 to 28 months on average. Some side effects are more serious than others contact your advice line if you have severe side effects, if they arent getting better or are getting worse. The researchers found that in the 3-month group, the 5-year overall survival rate was 82.6%, while in the 6-month group . People with colon cancer may have chemotherapy as part of their treatment. This study concluded that FOLFOX improves the long-term outcomes of patients with stage 3 coloncancer. This feeling of being unwell usually last for 4 to 7 days after treatment, and can continue to worsen after each cycle of treatment. FOLFOX chemo is given to shrink tumors and help decrease symptoms for a colon cancer patient. He is on the medical advisory board of EHE, Intl. Can FOLFOX be used as first-line therapy for Stage IV colon cancer? Lin X, Xu L, Tan H, Zhang X, Shao H, Yao L, Huang X. Heliyon. Adjuvant therapy is a cancer treatment administered after the primary treatment to help prevent relapse. T4 stage and preoperative anemia as prognostic factors for the patients with colon cancer treated with adjuvant FOLFOX chemotherapy. Because of an excellent tumor control and survival rate for patients who had a pCR after neoadjuvant treatment, nonoperative treatment has been suggested as management for such patients . The 5-year overall survival and disease-free survival rates did not show a significant difference. With an expected median survival time in the control group of 5 months, an accrual period of 3 years and a minimum . A chemotherapy pump is a device that delivers chemotherapy drugs into the body at a slow, controlled rate. It is now stage 4 and he is on an immuno-therapy called pazopanib. FOLFOX is a combination of chemotherapy drugs. Some cookies are placed by third party services that appear on our pages. FOIA Although only six courses of FOLFOX can increase the morbidity after a hepatic resection , the combinatorial use of bevacizumab may affect the decrease of sinusoidal obstruction . 2021 Aug;12(4):1509-1517. doi: 10.21037/jgo-20-593. If you cannot stand this drug, please last one me cycle. The 5-year overall survival rate of patients was 77.9 %, and the 3-year disease-free survival was 76.7 %. Dr. Saltz said that three questions about the study remain unanswered: The relative contribution of bolus vs 5-FU infusion to the study results, the relative contribution of oxaliplatin vs irinotecan, and the impact of second-line therapy on survival. There is no apparent pattern as to when nausea starts, how long it lasts, or how severe it is. Large-scale prospective studies are necessary for the analysis of complications and survival rates. Cookies are small text files that can be used by websites to make a user's experience more efficient. "Based on our data and that from other studies, there are currently three agents5-FU and its prodrugs, irinotecan, and oxaliplatinthat are active in the treatment of metastatic colorectal cancer," Dr. Goldberg said. After the 3 cycles we heard nothing and I had to contact the consultant myself regarding a re-scan because someone had omitted to book it in!. We now need to wait until the PET scan and the next appointment in November to find out when treatment will start. FLOX consists of the same drugs as FOLFOX but on a different dose and delivery schedule (older regimen). Sharif S, O'Connell MJ, Yothers G, Lopa S, Wolmark N. Cancer Invest. The median overall survival was 21.8 months and 16.4 months, respectively. Biliary tract cancer, which includes cancer of the bile ducts and gallbladder, is rare, with an estimated 11,980 new cases diagnosed in the United States in 2021. I hope you get the news you are hoping for at your next appointment in January. Deep meditation: Might it change the gut microbiome to boost health? All rights reserved. Primary the size of a small childs football, over 30 secondaries in my liver, 3 of them large than 5cm in diameter. The site is secure. sharing sensitive information, make sure youre on a federal They also had a 12% improvement in the odds of a better 3-year DFS and 22% improvement in the odds of a better 5-year overall survival. In this study, about 77% of study participants experienced disease-free survival for 3 years after using FOLFOX. If it is advanced colorectal cancer, or metastatic, then chemotherapy can still decrease disease symptoms and extend life. This means they administer the medication after the primary cancer treatment, such as surgery to remove a tumor. Andy will have a different one as the Folfox didn't work - I can't remember what the name of the other one is but the oncologist said there will be a daily injection to go with it (not sure what it's called either - sorry. Last medically reviewed on June 16, 2021. According to the National Cancer Institute, National Comprehensive Cancer Network guidelines. How much horsepower can you get out of a 250 inline 6? Five-year esophagus cancer survival rate. He is on an immuno- therapy treatment, Votient,as advance renal cell cancer doesn't respond well to traditional chemo, so he takes a pill everyday and is on it now until we see the oncologist in the new year. A person can use it alone or in combination with other drugs. The good news is that as we learn how . The 5-year relative survival rate for stage 4 colon cancer that has spread to . We were really shocked at this and couldn't really think straight in the doctor's office so we just nodded and tried to take it in. The gold standard clearly is survival, and that is what we would love to show. Clin Colorectal Cancer. XELOX every 3 weeks or FOLFOX every 2 weeks (n = 833); or nivolumab at 1 mg/kg plus ipilimumab (Yervoy) at 3 mg/kg every 3 weeks for 4 cycles, followed by nivolumab at 240 mg every 2 weeks (n = 409). Well I did. Bethesda, MD 20894, Web Policies FOLFOX can be broken down into other subtypes such as FOLFOX-4, FOLFOX-6, and FOLFOX-7 depending on how these three drugs are administered. Median overall survival with IFL was 14.1 months, with FOLFOX 18.6 months, and with IROX 16.5 months, Dr. Goldberg said. When provided by itself, oxaliplatin has an overall response rate of only 10%. Methods: In this analytical cross-sectional study, 47 patients treated with FOLFOX regimen and 57 patients treated with mDCF regimen were recruited, Patients in both groups were compared for demographic findings, response rate, mortality rate, overall survival (OS) and progression free survival (PFS). "We feel that the FOLFOX regimen has notable activity and an advantageous toxicity profile in comparison to IFL. FOIA Subscribe to: Posts (Atom) Among patients randomized to IFL, only 17% received oxaliplatin second line. Overall, 3000 patients (79.3%) received FOLFOX and 785 (20.7%) FOLFIRI. Noninferiority was demonstrated if the one-sided false discovery rate adjusted (FDRadj) P value was < .025. 8600 Rockville Pike A PICC is a long tube that inserts into your arm and releases the drug in the large central veins near your heart. Evaluation of the change of outcomes over a 10-year period in patients with stage III colon cancer: pooled analysis of 6501 patients treated with fluorouracil, leucovorin, and oxaliplatin in the ACCENT database. Influence of first line chemotherapy strategy depending on primary tumor location in metastatic colorectal cancer. We examine the success rates of chemotherapy for colon cancer and its side. Lancet Oncol. Taymeyah AT, et al. Do You Prefer a Treatment or a Cure for Cancer? Howeffective isFOLFOXchemotherapy treatment? Reason being, they didnt know what to do with me. (2021). The .gov means its official. Time to discontinuing protocol-specific chemotherapy (for any reason) was similar in the IFL and FOLFOX arms, but the reasons patients stopped treatment differed. But the number of new cases being diagnosed worldwide each year is increasing, said Dr. Oh. According to a 2016 study in Springerplus, there are significant benefits for people with stage 3 colon cancer who receive at least eight cycles of FOLFOX. Its often possible to adjust the dosage of your treatment to minimize side effects. The exact treatment you receive can vary depending on the type of FOLFOX you receive, but heres one example of what FOLFOX treatment may look like: Youll receive no treatment from days 3 to 14 until your next cycle starts.
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